Publications
Hoagland DA*, Rodríguez-Morales P*, Mann AO, Baez Vazquez AY, Yu S, Lai A, Kane H, Dang SM, Lin Y, Thorens L, Begum S, Castro MA, Pope SD, Lim J, Li S, Zhang X, Li MO, Kim CF, Jackson R, Medzhitov R, Franklin RA. Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage. Science. 2025 Jul; 389(6756):169-175. *contributed equally
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Hoagland DA, Franklin RA. Isolation of Live Myeloid and Epithelial Cell Populations from the Mouse Lung. J Vis Exp. 2025 Jan;(215):10.3791/67648.
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Wang G, Muñoz-Rojas AR, Spallanzani RG, Franklin RA, Benoist C, Mathis D. Adipose-tissue Treg cells restrain differentiation of stromal adipocyte precursors to promote insulin sensitivity and metabolic homeostasis. Immunity. 2024 Jun; 57(6):1345-1359.e5.
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Ysasi AB, Engler AE, Bawa PS, Wang F, Conrad RD, Yeung AK, Rock JR, Beane-Ebel J, Mazzilli SA, Franklin RA, Mizgerd JP, Murphy GJ. A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism. iScience. 2024 Jun; 27(7):110169.
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Rodríguez-Morales P, Franklin RA. Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis. Trends Immunol. 2023 Dec;44(12):986-998. doi: 10.1016/j.it.2023.10.004.
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Nixon BG, Kuo F, Ji L, Liu M, Capistrano K, Do M, Franklin RA, Wu X, Kansler ER, Srivastava RM, Purohit TA, Sanchez A, Vuong L, Krishna C, Wang X, Morse III HC, Hsieh JJ, Chan TA, Murphy KM, Moon JJ, Hakimi AA, Li MO. Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer. Immunity. 2022 Nov 8;55(11):2044-2058.e5. doi: 10.1016/j.immuni.2022.10.002.
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Zhou X*, Franklin RA*, Adler M, Carter TS, Condiff E, Adams TS, Pope SD, Philip NH, Meizlish ML, Kaminski N, Medzhitov R. Microenvironmental Sensing by Fibroblasts Controls Macrophage Population Size. Proc Natl Acad Sci USA. 2022 Aug; 119(32): e2205360119. *contributed equally
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González-Sánchez HM, Baek JH, Weinmann-Menke J, Ajay AK, Charles JF, Noda M, Franklin RA, Rodríguez-Morales P, Kelley VR. IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice. Lab Invest. 2022 Aug; doi: 10.1038/s41374-022-00772-0.
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Franklin RA. (2021) Fibroblasts and macrophages: Collaborators in tissue homeostasis. Immunol Rev. 302(1): 86-103.
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Meizlish ML*, Franklin RA*, Zhou X*, Medzhitov R. (2021) Tissue Homeostasis and Inflammation. Annu. Rev. Immunol. 39(1): 557-581. *contributed equally
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Franklin RA, Medzhitov R. (2020) Untangling iNKT Cell Function in Adipose Tissue Homeostasis. Cell Metab. 32(2): 148-149.
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Adler M, Mayo A, Zhou X, Franklin RA, Meizlish ML, Medzhitov R, Kallenberger SM, Alon U. Principles of cell circuits for tissue repair and fibrosis. iScience. 2020 Feb; 23(2): 100841.
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Allen NC, Philip NH, Hui L, Zhou X, Franklin RA, Kong Y, Medzhitov R. Desynchronization of the molecular clock contributes to the heterogeneity of the inflammatory response. Sci Signal. 2019 Mar; 12(571).
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Zhou X*, Franklin RA*, Adler M*, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R. Circuit design features of a stable two-cell system. Cell. 2018 Feb; 172(4): 744-757. *contributed equally
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Adler M, Mayo AE, Zhou X, Franklin RA, Jacox JB, Medzhitov R, Alon U. Endocytosis as a stabilizing mechanism for tissue homeostasis. Proc Natl Acad Sci USA. 2018 Feb; 115(8): E1926-E1935.
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Dadi S, Chhangawala S, Whitlock BM, Franklin RA, Luo CT, Oh SA, Toure A, Pritykin Y, Huse M, Leslie CS, Li MO. Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. Cell. 2016 Jan; 164(3): 365-377
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Franklin RA, Li MO. (2016) Ontogeny of Tumor-associated Macrophages and Its Implication in Cancer Regulation. Trends Cancer. 2(1): 20-34.
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Franklin RA, Liao W, Sarkar A, Kim MV, Bivona MR, Liu K, Pamer EG, Li MO. The cellular and molecular origin of tumor-associated macrophages. Science. 2014 May; 344(6186): 921-925.
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Donkor MK, Sarkar A, Savage PA, Franklin RA, Johnson LK, Jungbluth AA, Allison JP, Li MO. T-cell Surveillance of Oncogene-induced Prostate Cancer is Impeded by T-cell TGF-b1. Immunity. 2011 Jul; 35(1): 123-134.