Publications
Hoagland, D.A.*, Rodríguez-Morales, P.*, Mann, A.O., Yu, S., Lai, A., Baez Vazquez, A., Pope, S.D., Lim, J., Li, S., Zhang, X., Li, M.O., Medzhitov, R., Franklin, R.A. Macrophages control pathological interferon responses during viral respiratory infection. bioRxiv 2023.12.16.572019 (2023). PMID: 38168230 *contributed equally
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Rodríguez-Morales P., Franklin R.A. Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis. Trends Immunol. 2023 Dec;44(12):986-998. doi: 10.1016/j.it.2023.10.004.
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Nixon B.G., Kuo F., Ji L., Liu M,. Capistrano K., Do M., Franklin R.A., Wu X., Kansler E.R., Srivastava R.M., Purohit T.A., Sanchez A., Vuong L., Krishna C., Wang X., Morse Iii H.C., Hsieh J.J., Chan T.A., Murphy K.M., Moon J.J., Hakimi A.A., Li M.O. Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer. Immunity. 2022 Nov 8;55(11):2044-2058.e5. doi: 10.1016/j.immuni.2022.10.002.
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Zhou X.*, Franklin R.A.*, Adler M., Carter T.S., Condiff E., Adams T.S., Pope S.D., Philip N.H., Meizlish M.L., Kaminski N., Medzhitov R. Microenvironmental sensing by fibroblasts controls macrophage population size. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2205360119. doi: 10.1073/pnas.2205360119. *contributed equally
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González-Sánchez H.M., Baek J.H., Weinmann-Menke J, Ajay A.K., Charles J.F., Noda M, Franklin R.A., Rodríguez-Morales P.**, Kelley V.R. (2022) IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice. Lab Invest. doi: 10.1038/s41374-022-00772-0. **Franklin lab trainee
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Franklin R.A. (2021) Fibroblasts and macrophages: Collaborators in tissue homeostasis. Immunol Rev. 302(1): 86-103.
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Meizlish, M.L.*, Franklin, R.A.*, Zhou, X.*, Medzhitov, R. (2021) Tissue Homeostasis and Inflammation. Annu. Rev. Immunol. 39(1): 557-581. *contributed equally
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Franklin, R.A. and Medzhitov, R. (2020) Untangling iNKT Cell Function in Adipose Tissue Homeostasis. Cell Metab. 32(2): 148-149.
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Adler, M., Mayo, A., Zhou, X., Franklin, R.A., Meizlish, M.L., Medzhitov, R., Kallenberger, S.M., Alon, U. (2020) Principles of cell circuits for tissue repair and fibrosis. iScience. 23(2): 100841.
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Allen, N.C., Philip, N.H., Hui, L., Zhou, X., Franklin, R.A., Kong, Y., Medzhitov, R. (2019) Desynchronization of the molecular clock contributes to the heterogeneity of the inflammatory response. Sci Signal. 12(571).
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Zhou, X.*, Franklin, R.A.*, Adler, M.*, Jacox, J.B., Bailis, W., Shyer, J.A., Flavell, R.A., Mayo, A., Alon, U., Medzhitov, R. (2018) Circuit design features of a stable two-cell system. Cell. 172(4): 744-757. *contributed equally
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Adler, M., Mayo, A.E., Zhou, X., Franklin, R.A., Jacox, J.B., Medzhitov, R., Alon, U. (2018) Endocytosis as a stabilizing mechanism for tissue homeostasis. Proc Natl Acad Sci USA. 115(8): E1926-E1935.
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Dadi, S., Chhangawala, S., Whitlock, B.M., Franklin, R.A., Luo, C.T., Oh, S.A., Toure, A., Pritykin, Y., Huse, M., Leslie, C.S., and Li, M.O. (2016) Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. Cell. 164(3): 365-377.
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Franklin, R.A. and Li, M.O. (2016) Ontogeny of Tumor-associated Macrophages and Its Implication in Cancer Regulation. Trends Cancer. 2(1): 20-34.
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Franklin, R.A., Liao, W., Sarkar, A., Kim, M.V., Bivona, M.R., Liu, K., Pamer, E.G., Li, M.O. (2014) The cellular and molecular origin of tumor-associated macrophages. Science. 344(6186): 921-925.
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Donkor, M.K., Sarkar, A., Savage, P.A., Franklin, R.A., Johnson, L.K., Jungbluth, A.A., Allison, J.P., Li, M.O. (2011) T-cell Surveillance of Oncogene-induced Prostate Cancer is Impeded by T-cell TGF-b1. Immunity. 35(1): 123-134.